SS-31, also known as Elamipretide, Bendavia, or MTP-131, is a synthetic peptide that targets and improves mitochondrial function. Mitochondria generate ATP (the body’s primary energy molecule), regulate cellular homeostasis, and impact nearly all physiological systems. SS-31 is a mitochondrial-targeted antioxidant with extensive therapeutic potential: mitigating oxidative stress, suppressing inflammation, maintaining mitochondrial health, and preventing cellular apoptosis.
It has several advantages over natural antioxidants and plays a key role in treating mitochondrial dysfunction-related disorders.
Benefits
- Increased energy (most potent energy-boosting peptide available)
- Neutralizes free radicals and reverses oxidative stress damage
- Anti-aging
- Anti-inflammatory (including neuroinflammation)
- Supports memory and cognition
- Antifibrotic
- Beneficial for kidney disease (activates AMPK pathway)
- Fights insulin resistance
- May prevent or mitigate symptoms of:
- Cardiovascular disease
- Neurodegenerative conditions
- Asthma and COPD
- Age-related macular degeneration
- Cancer
- Barth syndrome
- Primary mitochondrial myopathy
- Duchenne muscular dystrophy
- Friedrich’s ataxia
Possible Side Effects
- Injection site irritation (redness, swelling, and/or itching)
- Gas
- Gastrointestinal upset
- Headache
- Dizziness
- Signs of an allergic reaction include: fast, erratic heartbeat; profuse sweating; shortness of breath; confusion; severe weakness; loss of coordination; stiff muscles and high fever; eye symptoms including blurred vision, tunnel vision, eye pain, swelling of the eyes, seeing halos around lights
Contraindications
- Do not use if pregnant or breastfeeding
- Do not use if hypersensitive to mitochondrial-targeted compounds
RECONSTITUTION & DOSING
12-week cycle followed by 4-8 week washout period
Subcutaneous administration
MORNING DOSING
SS-31: 10mg STANDARD PROTOCOL
Mix with 1mL (100 units) of BAC water
10 units-20 units(1mg), 1x/day, 7 days/week
SS-31: 10mg MAXIMUM PROTOCOL
Mix with 1mL (100 units) of BAC water
- Week 1: 10 units(1mg), 1x/day, 5 days/week
- Weeks 2–5: 20 units (2mg), 1x/day, 5 days/week
- Weeks 6–8: 30 units (3mg), 1x/day, 3 days/week
- Weeks 9–12: 40 units (4mg), 1x/day, 3 days/week
SS-31: 30mg STANDARD PROTOCOL
Mix with 3mL (300 units) of BAC water
10-20 units (1-2mg), 1x/day, 7 days/week
SS-31: 30mg MAXIMUM PROTOCOL
Mix with 3mL (300 units) of BAC water
- Week 1: 10 units(1mg), 1x/day, 5 days/week
- Weeks 2–5: 20 units (2mg), 1x/day, 5 days/week
- Weeks 6–8: 30 units (3mg), 1x/day, 3 days/week
- Weeks 9–12: 40 units (4mg), 1x/day, 3 days/week
Stacking Suggestions
- MOTS-C – run before an SS-31 cycle for maximum mitochondrial optimization. SS-31 primes the mitochondria, MOTS-C boosts cellular adaptation and metabolic health (Follow standard protocol for 10-14 days prior to start of MOTS-C protocol)
- NAD+ – supports ATP production and cellular repair when paired with SS-31
- Glutathione – enhances antioxidant defense and detoxification during oxidative stress repair
- CJC-1295 / Ipamorelin – supports cellular regeneration and recovery alongside mitochondrial repair
- AOD-9604 – assists with fat metabolism during energy-focused SS-31 cycles
- BPC-157 – promotes systemic healing and combats inflammatory stress