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Sermorelin is a synthetic version of growth hormone-releasing hormone (GHRH), which is naturally produced in the hypothalamus and stimulates the pituitary gland to release human growth hormone (HGH). HGH is involved in a number of vital biological processes, including tissue growth and repair, fat burning, muscle building, immune function, libido, and more.

Benefits of Sermorelin

  • Boosts energy, reducing lethargy and fatigue
  • Helps cells generate ATP
  • Increases metabolism
  • Builds lean muscle
  • Increases muscle strength and tone
  • Accelerates post-workout muscle recovery
  • Enhances cardiovascular endurance and cellular oxygen uptake
  • Reduces adipose fat tissue (especially abdominal fat)
  • Improves sleep quality
  • Boosts collagen synthesis, improving skin quality and appearance
  • Accelerates cellular regeneration
  • Increases bone density
  • Supports cognitive function through healthy GH levels

Side Effects

  • Injection site reaction (redness, swelling, itching)
  • Headaches
  • Fluid retention
  • Joint pain
  • Increased insulin sensitivity

Side effects are usually mild and temporary, typically resolving within the first few weeks of therapy.

Less common but more serious side effects include:

  • Dizziness
  • Flushing
  • Reduced blood pressure

Exercise caution if you are prone to allergies.

Contraindications

Do NOT use Sermorelin if:

  • You have cancer
  • You have diabetic retinopathy
  • You have an acute critical illness
  • You are taking glucocorticoids or thyroid medications (consult your doctor)
  • You have Prader-Willi syndrome (consult a physician)

Dosing Protocol

Sermorelin: 5 mg vial
Mix with 3 mL (300 units) of bacteriostatic water
Subcutaneous administration
Cycle length: 12–16 weeks, followed by a 4–6 week washout period
Take dose at bedtime, at least 1 hour after your last meal
Dose 5 days per week, with 2 consecutive days off

Standard Dosing Protocol

  • 12 units = 200 mcg (Weeks 1–4)
  • 18 units = 300 mcg (Weeks 5–8)
  • 24 units = 400 mcg (Weeks 9–12)
  • 30 units = 500 mcg (Weeks 13–16)

Maximum Dosing Protocol

  • 18 units = 300 mcg (Weeks 1–4)
  • 24 units = 400 mcg (Weeks 5–8)
  • 30 units = 500 mcg (Weeks 9–12)
  • 36 units = 600 mcg (Weeks 13–16)

Dosing Guidelines by Sex (General Use)

  • Men: 200–300 mcg daily
  • Women: 100–150 mcg daily

Follow a 5-on, 2-off weekly schedule. Best taken at night for maximum GH pulsatility.

Stacking Suggestions

  • Ipamorelin – synergistic GH secretagogue that increases growth hormone output without raising cortisol or prolactin
  • CJC-1295 (No DAC) – boosts GH pulsatility when paired with Sermorelin
  • BPC-157 or TB-500 – accelerate muscle recovery and improve soft tissue repair
  • AOD-9604 – promotes fat burning and body recomposition alongside Sermorelin’s anabolic effects
  • Glutathione or NAD+ – support mitochondrial health and anti-aging effects during long-term hormone optimization
  • L-Arginine or GABA – may further enhance natural GH production when combined with Sermorelin before sleep

Sermorelin + Ipamorelin is one of the most clinically supported stacks for long-term GH optimization.